Hydrazide-Hydrazones in the Synthesis of 1,3,4-Oxadiazine, 1,2,4-Triazine and Pyrazole Derivatives with Antitumor Activities
نویسندگان
چکیده
The reaction of cyanoacetyl hydrazine (1) with the -haloketones 2a-2c in 1,4-dioxane afforded the hydrazidehydrazone derivatives 3a-3c. The latter products were used in a series of heterocyclization to give 1,3,4-oxadiazine, 1,2,4triazine and pyrazole derivatives. All compounds synthesized through this work are new products and their antitumor evaluation towards three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). Some of the synthesized products showed high inhibitory effect towards the three cell lines.
منابع مشابه
Novel Synthesis of Hydrazide-hydrazone and Their Uses for the Synthesis 1,3,4-oxadiazine, 1,2,4-triazine, Pyrazole and Pyridazine Derivatives with Antimicrobial and Antifungal Activities
The reaction of the cyanoacetylhydrazine (1) with α-bromoketones (2a-c) gave the hydrazide-hydrazone derivatives 3a-c. The latter compounds underwent ready cyclization when heated in sodium ethoxide to form the 1,3,4-oxadiazine derivatives 4a-c. The reaction of 3a with hydrazines gave the 1,3,4-triazine derivatives 7a,b. Compounds 3a-c and 7a,b underwent some heterocyclizations when treated wit...
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